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pentobarbital will lower the level or result of quinine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can cut down panobinostat concentrations by ~70% and caus